How to write a retrospective case series

January 23, Guidance for investigators regarding case reports and case studies The Health Sciences IRB Office frequently receives queries regarding whether publishing a case report constitutes human subjects research and therefore requires IRB review. Case reports generally involve the description of medical treatment in a patient or a few patients with a unique treatment, disease course, or outcome based on a retrospective review of medical records or they can involve a description of a unique diagnostic finding or uncommon presentation.

How to write a retrospective case series

Dijkstra introduces the topic of his letter, which is that he has noticed that goto statements are mostly detrimental how to write a retrospective case series the programs in which they appear. He proposes that goto statements should be abolished from all high-level programming languages.

My first remark is that, although the programmer's activity ends when he has constructed a correct program, the process taking place under control of his program is the true subject matter of his activity, for it is this process that has to accomplish the desired effect; it is this process that in its dynamic behavior has to satisfy the desired specifications.

Yet, once the program has been made, the "making" of the corresponding process is delegated to the machine.

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This paragraph of technically dense verbiage is fairly typical of Dijkstra's academic writing style. This just means that the actual activity performed by a programmer is not simply writing programs, but controlling the action of the code as it is executed on an actual machine.

However, he states, once the programmer has written a working program, the actual execution of the program is entirely under the control of the machine itself. Dijkstra uses the term correct to describe a program that has no errors, or in current parlance, has no bugs.

This terminology reflects the belief at the time that code could be written which could be formally verified, i. My second remark is that our intellectual powers are rather geared to master static relations and that our powers to visualize processes evolving in time are relatively poorly developed.

For that reason we should do as wise programmers aware of our limitations our utmost to shorten the conceptual gap between the static program and the dynamic process, to make the correspondence between the program spread out in text space and the process spread out in time as trivial as possible.

Here Dijkstra observes that humans are better at visualizing static relationships than dynamic relationships. Thus, he argues, we should minimize the difference between the two when expressed as program code, so that the dynamic nonconstant aspects of the program are evident in the structure of the source code itself.

This is generally true in most current programming languages, the majority of which operate in a linear, statement-by-statement fashion.

how to write a retrospective case series

However, to some extent Dijkstra's principle has not been fully realized when we observe the complexity that must be dealt with by real-world programming tasks, such as multitasking, multithreading, interrupt handling, volatile hardware registers, virtual memory paging, device latency, real-time event handling, and so forth, just to name a few.

Today's programming problems are no longer sufficiently handled by simple one-line-at-a-time execution programming models. Let us now consider how we can characterize the progress of a process.

You may think about this question in a very concrete manner: Dijkstra begins to construct a formal definition of program execution, or what he calls progress of a process. It must be remembered that many of the terms we take for granted today were not firmly established place at the time, and there was no commonly accepted language or pseudo-language in use for discusing algorithms and programs.

Today, of course, a writer would use a concrete language such as C, Java, Pascal, LISP, or a pseudo-language bearing a strong resemblance to one of these languages as a lingua franca for illustrating programming concepts. Let us call such a pointer to a suitable place in the text a "textual index.

Eric Burdon and the Animals were, and still are, regardless of what some folks think, one of the "supergroups" of the 60's and 70's and part of what is referred to as "The British Invasion", even though at times, they seemed more American than their counterparts. The case method is a teaching approach that uses decision-forcing cases to put students in the role of people who were faced with difficult decisions at some point in the past. It developed during the course of the twentieth-century from its origins in the casebook method of teaching law pioneered by Harvard legal scholar Christopher C. sharp contrast to many other teaching methods. For retrospective study, you should not calculate the sample for your particular study. But, you should mentioned the study period like in months or in years.

This reflects the dual nature of programming tasks that he mentioned previously, these being related to the sequential nature of executing one statement or action after another, i. His term textual index is essentially a program counter. However, he is attempting to go beyond simply tracking the location of the current execution thread, to making an explicit connection between a statement in the source code text and a program execution state.

Dijkstra introduces more complex flow control statements such as if-then-else conditional statements and case a.

This reflects the fact that, at the time, much effort was being made to formulate the best minimal set of flow control structures for programming languages and for programming theory in general.

A major goal of all of this effort was to create a nomeclature that could be used not just for actual programming languages, but which also could be used directly for mathematical formulations of programming algorithms.

As soon as we include in our language procedures we must admit that a single textual index is no longer sufficient. With the inclusion of procedures we can characterize the progress of the process via a sequence of textual indices, the length of this sequence being equal to the dynamic depth of procedure calling.

This is an observation that a single statement pointer is not sufficient to define the state of an executing program if the program employs subroutines variously known as procedures, functions, or methods. This reflects what is known in modern parlance as a call stack, which is an array of program counters a.In the social sciences and life sciences, a case study is a research method involving an up-close, in-depth, and detailed examination of a subject of study (the case), as well as its related contextual conditions..

Case studies can be produced by following a formal research method. These case studies are likely to appear in formal research venues, as journals and professional conferences.

how to write a retrospective case series

Retrospective studies are designed to analyse pre-existing data, and are subject to numerous biases as a result Retrospective studies may be based on chart reviews (data collection from the medical records of patients) Types of retrospective studies include.

A retrospective case series is the description of a group of cases with a new or unusual disease or treatment.

With a case-control study, cases with and without the condition of interest are identified. Case series and Case reports consist of collections of reports on the treatment of individual patients or a report on a single patient.

Because they are reports of cases and use no control groups. A case series (also known as a clinical series) is a type of medical research study that tracks subjects with a known exposure, such as patients who have received a similar treatment, or examines their medical records for exposure and outcome.

However, no causal inferences should be made from case series regarding the efficacy of the investigated treatment. This article will provide principles for the design, analysis, and reporting of case series, illustrated by examples from the orthopaedic surgical literature.

Case Report Publication Guidance: IRB Review and HIPAA Compliance